No, the 4th generation DIY Mini Splits are designed to use R-410A refrigerant. None of our R-410A products are compatible with R-454B products due to the changes made to support the new refrigerant. Additionally, R-410A and R-454B refrigerants should never be mixed, as they are not compatible with each other. Always use the recommended refrigerant for your specific system to ensure optimal performance and safety.
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